Combining experimental and computational approaches to study RNA regulation in adaptive immunity and autoimmune disease
We are working on understanding how nuclear condensates and cytoplasmic interactions affect the production of inflammatory molecules
- McIntyre, Tschan, et al., 2025
- Tschan, et al., 2025
- Gokhale, McIntyre et al., 2020 (mRNA regulation in infection)
- McIntyre et al., 2020 (mRNA regulation)
Using proximity labelling and high-throughput imaging approaches, we are characterizing cellular heterogeneity in patient and donor samples
We are developing pre-clinical targeted approaches to reduce autoreactivity using short oligonucleotides and optimizing delivery to primary B cells
We are interested in the uncharacterized immune systems of odd and less studied single-cell creatures
